An efficient and mild methodology for rapid and efficient synthesis of isatin Schiff bases was described under microwave irradiation and solvent free condition.aromatic or heterocyclic Primary amines and isatin could be selectively reacted under microwave irradiation into the corresponding isatin Schiff bases in high yields and short reaction time.  

In this study, a series of isatin-based Mannich bases were prepared and their biological activity was evaluated. Schiff bases of isatin were synthesized by condensation of the keto group of isatin with different aromatic primary amines. The NMannich bases of the above Schiff bases were synthesized by reaction of the acidic imino group of isatin with formaldehyde and secondary amine. The chemica...

The aim of the present study is to synthesize the oxovanadium complex of the V3+ ion with isatin sciff bases. Spectroscopic methods have been used to confirm these models of complexation and to understand the structures of the species formed in methanolic solution. We also have isolated a complex of Vanadium (III) with isatin schiff bases in the solid phase.

The aim of the present study is to synthesize the oxovanadium complex of the V3+ ion with isatin sciff bases. Spectroscopic methods have been used to confirm these models of complexation and to understand the structures of the species formed in methanolic solution. We also have isolated a complex of Vanadium (III) with isatin schiff bases in the solid phase.

Isatin is a heterocyclic molecule that belongs to one of the most important classes organic compounds known as indolines. Isatin, isatin analogs, and their Schiff bases have recently attracted lot attention in medicinal chemistry. itself, shows various biological activities such antiviral, anticancer, antimicrobial, anti-inflammatory, analgesic, antioxidant, anticonvulsant. Bis- containing moie...

A media consisting of isatin-Schiff bases and its inclusion complexes with β-cyclodextrine was developed to maximize the production of antibiotics Hexaene H-85 and azalomycine B by Streptomyces hygroscopicus CH-7. The media with β-cyclodextrine inclusion complex of isatin-3-thiosemicarbazone resulted in the maximum antibiotics concentration of 493 μg/cm for Hexaene H-85 and 191 μg/cm for azalom...

The aim of the present study is to synthesize the oxovanadium complex of the V3+ ion with isatin sciff bases. Spectroscopic methods have been used to confirm these models of complexation and to understand the structures of the species formed in methanolic solution. We also have isolated a complex of Vanadium (III) with isatin schiff bases in the solid phase.

Twelve new bis-Schiff bases of isatin, benzylisatin and 5-fluoroisatin 3a-3l were prepared by condensation of isatin, benzylisatin and 5-fluoroisatin with primary aromatic amines. The chemical structures of the products were confirmed by 1H- and 13CNMR, IR and mass spectral data. The compounds were screened for antiviral activity against a panel of DNA and RNA viruses. Minimum cytotoxic and min...

Schiff bases of N-methyl and N-acetyl isatin derivatives with different aryl amines have been synthesized and screened for anticonvulsant activities against maximal electroshock (MES) and subcutaneous metrazole (ScMet). N-methyl-5-bromo-3-(p-chlorophenylimino) isatin (2) exhibited anticonvulsant activity in MES and ScMet with LD50 > 600 mg kg(-1), showing better activity than the standard drugs...

Condensation of aromatic primary bis-amines with isatin (1H-indole-2,3-dione) and 5-flouroisatin occurred cleanly and efficiently in a water suspension medium without using any organic solvent or acid catalyst. The corresponding bis-Schiff bases were obtained in good yields and were easily isolated by filtration. Their structures were confirmed by (1)H-NMR, (13)C-NMR, IR and mass spectra.